INFLUENCE OF DI-BUTYLTIN DILAURATE ON BRAIN NEUROTRANSMITTER SYSTEMS AND BEHAVIOR IN RATS
INFLUENCE OF DI-BUTYLTIN DILAURATE ON BRAIN NEUROTRANSMITTER SYSTEMS AND BEHAVIOR IN RATS
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DOI：
10.1007/bf00334618
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发表时间：
1988-01-01
影响因子：
6.1
通讯作者：
SETH, PK
中科院分区：
文献类型：
--
作者：
ALAM, MS;HUSAIN, R;SETH, PK
暴露于DBTL(20、40或80 mg/kg体重)可导致所有处理水平的去甲肾上腺素(NA)、多巴胺(DA)和5-羟色胺(5-HT)水平下降。下丘脑和额叶皮质似乎受到的影响最大，因为所检测的所有三种胺的水平在这些区域都发生了变化。纹状体DA下降幅度最大，延髓NA下降幅度最大，额叶5-羟色胺下降幅度最大。这些动物还表现出在所有剂量下自发活动和学习的减少。数据表明，DBTL的神经毒性涉及下丘脑和大脑额叶皮质区域。
Exposure to DBTL (20, 40 or 80 mg/kg body weight) caused a decrease in levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) at all treatment levels. Hypothalamus and frontal cortex appeared to be most affected, since levels of all the three amines examined showed changes in these areas. Maximum decrease of DA was found in corpus striatum, NA in pons medulla and of 5-HT in frontal cortex. These animals also showed a decrease in spontaneous locomotor activity and learning at all the doses. The data indicates involvement of hypothalamus and frontal cortical regions of the brain in the neurotoxicity of DBTL.