Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus
Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus
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DOI：
10.1099/vir.0.81213-0
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发表时间：
2005-12-01
影响因子：
3.8
通讯作者：
Hewson, R
中科院分区：
文献类型：
--
作者：
Chamberlain, J;Cook, N;Hewson, R
布尼亚病毒科的内罗病毒属包括克里米亚-刚果出血热（CCHF）种群。该物种主要由危害组4病原体，其名称和大多数菌株条目均来源于该病原体。此外，该种属还包括根据抗原交叉反应性分类为成员的危险组2病毒。CCHF病毒具有由大（L）、中（M）和小（S）区段组成的三重RNA基因组。在这里，以前未描述的L和S段的新菌株起源于中东和非洲的序列特征的报告。在其他公开的序列信息的背景下，用系统发育工具进一步审查这些数据，揭示了L和S片段之间类似的分组模式。这些组与菌株分离的地理分布相关，并表明CCHF病毒的L和S片段一起进化。
The genus Nairovirus of the family Bunyaviridae includes the Crimean-Congo haemorrhagic fever (CCHF) species group. The species is predominated by the hazard-group 4 pathogens, from which the name and majority of strain entries are derived. Additionally, the species embraces hazard-group 2 viruses that are classified as members by antigenic cross-reactivity. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. Here, the sequence characterization of previously undescribed L and S segments from novel strains originating in the Middle East and Africa is reported. Further scrutiny of this data with phylogenetic tools, in the context of other publicly available sequence information, reveals analogous grouping patterns between the L and S segments. These groups correlate with the geographical distribution of strain isolation and indicate that the L and S segments of CCHF viruses have evolved together.