Enhanced biotransformation of theophylline in marihuana and tobacco smokers
Enhanced biotransformation of theophylline in marihuana and tobacco smokers
复制标题
增强大麻和吸烟者茶碱的生物转化
DOI：
10.1002/cpt1978244406
复制
发表时间：
1978
影响因子：
6.7
通讯作者：
A. Yurchak
中科院分区：
文献类型：
--
作者：
W. Jusko;Jerome J. Schentag;J. H. Clark;M. Gardner;A. Yurchak
Single oral doses of theophylline were administered to 7 chronic marihuana smokers, to 7 chronic users of both marihuana and tobacco, and to 43 appropriate control subjects. Theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers with a mean increase in total clearance from 52 ml/kg/hr in nonsmokers to 74 ml/kg/hr in subjects who smoked either material alone. There was an additive increase in clearance to 93 m/lkg/hr in those who smoked both substances. Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers.
