Spinal cord stimulation and cerebral haemodynamics
Spinal cord stimulation and cerebral haemodynamics
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脊髓刺激和脑血流动力学
DOI：
10.1007/bf01402512
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发表时间：
2005
影响因子：
2.4
通讯作者：
S. Sandric
中科院分区：
文献类型：
--
作者：
Mario Meglio;Beatrice Cioni;Massimiliano Visocchi;Flavio Nobili;G. Rodriguez;Guido Rosadini;F. Chiappini;S. Sandric
Hosobuchi（1986）和Meglioet al.（1988）使用133-氙冲洗技术在人的脊髓刺激（SCS）过程中显示局部脑血流量（rCBF）增加。本文报告了SCS对CBF的影响，用两种不同的技术测量：8例患者进行了133-核素显像，28例患者进行了经颅多普勒超声（TCD）检查，其中2例同时进行了两项检查。本研究的目的是：1-验证SCS对CBF的影响，2-比较两种不同方法的观察结果，3-评估刺激脊髓节段水平和CBF改变之间可能的相关性。我们的研究结果证实，SCS与CBF的调节机制相互作用。在同一患者的不同脊髓水平的刺激可以产生不同的效果，并且这种效果是可重复的。刺激颈髓更可能引起CBF增加。在两种方法研究的患者中，SCS引起的CBF变化的标志是相同的。最后，在两个患者中，SCS对CO2自动调节的影响进行了研究。这种研究的结果，虽然初步的，表明，CO2和SCS有竞争力的影响后，CBF的调节机制。
SummaryAn increase of regional cerebral blood flow (rCBF) has been shown to occur in man during spinal cord stimulation (SCS) by Hosobuchi (1986) and by Meglioet al. (1988) using the 133-Xenon wash-out technique.In this paper we report the effects of SCS on CBF as measured by two different techniques: 8 patients were studied with the 133-Xe method and 28 with the transcranial doppler sonography (TCD), in two cases both studies were performed. The aim of our study was to: 1-verify the effect of SCS on CBF, 2-compare observations made by two different methods, and 3-evaluate a possible correlation between the stimulated spinal segmental level and the modification of CBF. The results of our study confirm that SCS interacts with the mechanisms of regulation of CBF. The stimulation of different spinal cord levels in the same patient can produce different effects and such effects are reproducible. An increase of CBF is more likely to occur with the stimulation of the cervical spinal cord. In patients studied by both methods the sign of CBF changes induced by SCS was the same.Finally, in two patients the effect of SCS on CO2 autoregulation was studied with the TCD. The results of such a study, although preliminary, suggest that CO2 and SCS have a competitive effect upon the mechanisms of regulation of CBF.