Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine
Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine
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DOI：
10.1097/00001756-200412030-00016
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发表时间：
2004-12-03
期刊：
影响因子：
1.7
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Bland, ST;Schmid, MJ;Maier, SF
Uncontrollable, but not controllable, stress produces a persistent potentiation of morphine-induced nucleus accumbens dopamine (DA) efflux and morphine-induced medial prefrontal cortex serotonin (5-HT) efflux. Here we investigate medial prefrontal cortex 5-HT mediation of this potentiation. Male Sprague-Dawley rats received bilateral medial prefrontal cortex microinjections of the neurotoxin 5,7-dihydroxytriptamine (5,7-DHT, 8 mug/mul/side), which selectively depleted medial prefrontal cortex 5-HT, or vehicle (Sham), and cannula implantation in the nucleus accumbens shell. After 2 weeks, rats received either uncontrollable stress or no stress. Microdialysis and morphine (3 mg/kg) treatment were performed the following day. Morphine produced an enhanced increase in DA in the Stress-Sham group that was completely blocked by 5,7-DHT lesions, suggesting that S-HT in the medial prefrontal cortex mediates this potentiation.
