Dissociation of Vasoreactivity to Acetazolamide and Hypercapnia
Dissociation of Vasoreactivity to Acetazolamide and Hypercapnia
复制标题
乙酰唑胺血管反应性的解离和高碳酸血症
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
KenjiMitsumori
中科院分区：
文献类型：
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作者：
KenKazumata;NaruhikoTanaka;TatsuyaIshikawa;SatoshiKuroda;KiyohiroHoukin;KenjiMitsumori
Background and Purpose The aim of this study was to compare the effect of vasodilative stimuli for the measurement of cerebrovascular reactivity obtained by acetazolamide and hypercapnia in patients with chronic occlusive major cerebral artery disease. Methods We examined 24 patients with unilateral occlusive lesions of a major cerebral artery using the 133Xe inhalation technique and single-photon emission CT. Regional cerebral blood flow (CBF) was measured during a resting state, during inhalation of 5% CO2, and 15 minutes after the administration of acetazolamide consecutively in the same patients. Normative values of resting CBF and acetazolamide reactivity were obtained in 21 normal subjects. Results All patients with the exception of 1 showed an increase in CBF during hypercapnia ipsilateral to the occlusive lesion. Ipsilateral acetazolamide reactivity was preserved in 13 patients. Conversely, 11 patients showed an absent response or paradoxical CBF reduction. Ipsilateral CO2 reactivity did not corre...
