Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants.
Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants.
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DOI：
10.1038/s41398-022-02268-3
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发表时间：
2022-12-07
影响因子：
6.8
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
--
作者：
Hu, He-Ying;Zhang, Ya-Ru;Aerqin, Qiaolifan;Ou, Ya-Nan;Wang, Zuo-Teng;Cheng, Wei;Feng, Jian-Feng;Tan, Lan;Yu, Jin-Tai
多重发病（存在两种或多种长期病症 [LTC]）被认为会加剧神经元损伤。多种疾病对痴呆症的影响尚未完全阐明。我们的目的是调查多发病与痴呆风险之间的关联。我们使用了 245,483 名英国生物银行参与者在 9 年随访期间的前瞻性数据。根据 LTC 计数和多发病模式评估多发病状态。针对潜在混杂因素进行调整的 Cox 回归模型用于检查多发病状态与全因痴呆 (ACD)、阿尔茨海默病 (AD) 和血管性痴呆 (VD) 的关联。基线时患有多种疾病的参与者患 ACD 和 VD 的风险较高，并且风险随着 LTC 计数的增加而升高（ACD：2 个 LTC 时风险比 [HR] = 1.15，95% 置信区间 [CI] = 1.01–1.31；HR = 1.18，CI = 1.01–1.39 3 个 LTC；HR = 1.65，CI = 1.44–1.88，≥4 个 LTC；VD：HR = 1.66，CI = 1.24–2.21，2 个 LTC；HR = 2.10，CI = 1.53–2.88 LTC；HR = 3.17，CI = 2.43–4.13（≥4 个 LTC）。具有 ≥4 个 LTC 的参与者也有较高的 AD 风险（HR = 1.34，CI = 1.08–1.66）。患有心脑血管/呼吸/代谢/肌肉骨骼/抑郁多病的参与者发生 ACD 的可能性是其他人的 1.46、1.28 和 2.50 倍分别为（HR = 1.46，95% CI = 1.28–1.67）、AD（HR = 1.28，CI = 1.04–1.58）和VD（HR = 2.50，CI = 1.90–3.27）。肿瘤/泌尿生殖系统/消化系统疾病的 ACD 风险增加 11%（HR = 1.11，CI = 1.00–1.24），VD 风险增加 73%（HR = 1.73，CI = 1.37–2.18），预防 LTC 积累和识别特定的多发病模式可能是有益的。预防痴呆及其亚型、AD 和 VD。
Multimorbidity (the presence of two or more long-term conditions [LTCs]) was suggested to exacerbate the neuronal injuries. The impact of multimorbidity on dementia has not been fully elucidated. We aimed to investigate the association between multimorbidity and dementia risk. We used the prospective data from 245,483 UK Biobank participants during a 9-year follow-up. Multimorbidity status was evaluated based on the LTC counts and multimorbidity patterns. Cox regression models adjusted for potential confounders were used to examine the associations of multimorbidity status with all-cause dementia (ACD), Alzheimer’s disease (AD) and vascular dementia (VD). Participants with multimorbidity at baseline had higher risks of ACD and VD, and the risks were elevated with the increase of LTC counts (ACD: hazard ratios [HR] = 1.15, 95% confidence intervals [CI] = 1.01–1.31 with 2 LTCs; HR = 1.18, CI = 1.01–1.39 with 3 LTCs; HR = 1.65, CI = 1.44–1.88 with ≥4 LTCs; VD: HR = 1. 66, CI = 1.24–2.21 with 2 LTCs; HR = 2.10, CI = 1.53–2.88 with 3 LTCs; HR = 3.17, CI = 2.43–4.13 with ≥4 LTCs). Participants with ≥4 LTCs also had a higher risk of AD (HR = 1.34, CI = 1.08–1.66]. Participants with the cardio-cerebrovascular/respiratory/metabolic/musculoskeletal/depressive multimorbidity were 1.46, 1.28, and 2.50 times more likely to develop ACD (HR = 1.46, 95% CI = 1.28–1.67), AD (HR = 1.28, CI = 1.04–1.58), and VD (HR = 2.50, CI = 1.90–3.27), respectively. Those with tumor/genitourinary/digestive disorders had a 11% higher hazard of ACD (HR = 1.11, CI = 1.00–1.24) and a 73% elevated risk of VD (HR = 1.73, CI = 1.37–2.18). The prevention of LTC accumulation and the identification of specific multimorbidity patterns might be beneficial to the prevention of dementia and its subtypes, AD as well as VD.
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影响因子：
105.7
作者：
Ben Hassen, Celine;Fayosse, Aurore;Landre, Benjamin;Raggi, Martina;Bloomberg, Mikaela;Sabia, Severine;Singh-Manoux, Archana
通讯作者：
Singh-Manoux, Archana
DOI：
10.3390/diagnostics11050760
发表时间：
2021-04-23
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Chen YL;Chen J;Wang HT;Chang YT;Chong SZ;Hsueh S;Chung CM;Lin YS
通讯作者：
Lin YS
影响因子：
2.2
作者：
Harsch, I. A.;Kaestner, R. H.;Konturek, P. Ch
通讯作者：
Konturek, P. Ch
影响因子：
5.3
作者：
Chen, Hsing-Yu;Yang, Yin Miranda;Noble, Mark
通讯作者：
Noble, Mark
影响因子：
5.2
作者：
Du, Xianglin L.;Cai, Yi;Symanski, Elaine
通讯作者：
Symanski, Elaine