PET/CT alignment calibration with a non-radioactive phantom and the intrinsic Lu-176 radiation of PET detector
PET/CT alignment calibration with a non-radioactive phantom and the intrinsic Lu-176 radiation of PET detector
复制标题
使用非放射性体模和 PET 探测器固有的 Lu-176 辐射进行 PET/CT 对准校准
DOI：
10.1016/j.nima.2016.08.012
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Dai Tiantian
中科院分区：
文献类型：
--
作者：
Wei Qingyang;Ma Tianyu;Wang Shi;Liu Yaqiang;Gu Yu;Dai Tiantian
正电子发射断层扫描/计算机断层扫描(PET/CT)是临床研究和临床前研究的重要工具，它同时提供功能和解剖图像。为了实现高质量的PET/CT图像配准，PET和CT扫描仪的对准校准是一个关键步骤。已报道的方法使用正电子源体模，由正电子正电子断层扫描仪和CT扫描仪成像，然后从这两种模式的重建图像中推导出变换矩阵。本文提出了一种利用非放射性体模和PET探测器固有的176Lu辐射进行PET/CT校准的新方法。首先，设计了一个无正电子源的多钨合金球形体模，并利用LYSO中包含的本征176Lu辐射对其进行了CT和PET扫描。其次，用自动程序求出球体的质心并进行匹配。最后，对质心数据进行最小二乘拟合，得到旋转矩阵和平移向量。将该方法应用于本实验室研制的动物PET/CT系统(InliView-3000)。实验结果表明，该方法具有较高的测量精度，完全可以替代传统的正电子源测量方法。
Positron emission tomography/computed tomography (PET/CT) is an important tool for clinical studies and pre-clinical researches which provides both functional and anatomical images. To achieve high quality co-registered PET/CT images, alignment calibration of PET and CT scanner is a critical procedure. The existing methods reported use positron source phantoms imaged both by PET and CT scanner and then derive the transformation matrix from the reconstructed images of the two modalities. In this paper, a novel PET/CT alignment calibration method with a non-radioactive phantom and the intrinsic176Lu radiation of the PET detector was developed. Firstly, a multi-tungsten-alloy-sphere phantom without positron source was designed and imaged by CT and the PET scanner using intrinsic176Lu radiation included in LYSO. Secondly, the centroids of the spheres were derived and matched by an automatic program. Lastly, the rotation matrix and the translation vector were calculated by least-square fitting of the centroid data. The proposed method was employed in an animal PET/CT system (InliView-3000) developed in our lab. Experimental results showed that the proposed method achieves high accuracy and is feasible to replace the conventional positron source based methods.