A New Benzophenanthridine Alkaloid from Caloncoba Glauca
A New Benzophenanthridine Alkaloid from Caloncoba Glauca
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DOI：
10.1177/1934578x1701200314
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发表时间：
2017-03
影响因子：
1.8
通讯作者：
Jabar B P A A Agbo-Jabar-B-P-A-A-Agbo-123405967;J. Mpetga;R. Bikanga;R. Tchuenguem;R. Tsafack;M. Awouafack;J. Dzoyem;Takuya Ito;H. Morita;P. Tane
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文献类型：
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作者：
Jabar B P A A Agbo-Jabar-B-P-A-A-Agbo-123405967;J. Mpetga;R. Bikanga;R. Tchuenguem;R. Tsafack;M. Awouafack;J. Dzoyem;Takuya Ito;H. Morita;P. Tane
从青花Caloncoba glauca茎皮中分离到3种生物碱，其中包括一种新生物碱n -甲酰二氢chelerythrine(1)，以及另外4种已知化合物。通过光谱和质谱分析证实了新化合物的结构。这是首次报道的从龙舌兰属提取的生物碱。芝麻素(4)[MIC = 256 μg/mL（白色念珠菌）]和二氢chelerythrine (2) [MIC = 32（白色念珠菌和副念珠菌）和128 μg/mL（克鲁塞念珠菌）]具有中至弱的抗真菌活性。
Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL (Candida albicans) and dihydrochelerythrine (2) [MIC = 32 (C. albicans and C. parapsilosis), and 128 μg/mL (C. krusei)] had moderate to weak antifungal activity.