ANALYSIS OF EMISSION TOMOGRAPHIC SCAN DATA - LIMITATIONS IMPOSED BY RESOLUTION AND BACKGROUND
ANALYSIS OF EMISSION TOMOGRAPHIC SCAN DATA - LIMITATIONS IMPOSED BY RESOLUTION AND BACKGROUND
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DOI：
10.1097/00004728-198406000-00028
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发表时间：
1984-01-01
影响因子：
1.3
通讯作者：
EDEN, M
中科院分区：
文献类型：
--
作者：
KESSLER, RM;ELLIS, JR;EDEN, M
正电子发射断层扫描[PET]扫描数据的正确分析需要仔细了解所使用的断层扫描系统的局限性，以便能够以符合这些局限性的方式收集和采样扫描数据。研究了分辨率所带来的一些限制。通常的成像情况，例如，218 FDG [氟脱氧葡萄糖]、C15 O2或15 O2涉及在所有3个维度上对有限大小的结构进行成像，这些结构可能相对于某些背景活性水平表现出温暖或凉爽。在发射断层摄影中，经常强调在给定平面内进行充分数据采样的重要性。然而，很少有人注意到临床扫描的适当z轴采样。从扫描中实际选择感兴趣区域可能对随后的统计分析产生重大影响。以前的工作对这个问题进行了实验研究的对象大小的关系，定量估计在热点冷背景的情况下的1-和2维的情况下。计算了热点-冷背景情况下的近似三维恢复系数。对上述因素的检查，具有不同对比度的3维对象，z轴采样和感兴趣区域的选择，尚未在文献中得到解决。本次调查研究了这些因素。
The proper analysis of positron emission tomographic [PET] scan data requires a careful knowledge of the limitations of the tomographic system used so that scan data can be collected and sampled in a manner consistent with those limitations. Some of the limitations imposed by resolution were studied. The usual imaging situation, e.g., 218FDG [fluorodeoxyglucose], C15O2, or 15O2, involves imaging structures of limited size in all 3 dimensions which may appear either warm or cool in relation to some background level of activity. In emission tomograpy the importance of adequate data sampling within a given plane has been frequently emphasized. Little attention, however, has been given to proper z axis sampling for clinical scanning. The actual selection of regions of interest from scans can have a significant impact on the subsequent satistical analysis. Previous work on this subject has experimentally examined the relationship of object size to quantitative estimation in the hot spot-cold background situation for the 1- and 2-dimensional cases. Approximate 3-dimensional recovery coefficients for the hot spot-cold background situation were calculated. An examination of the factors discussed above, 3-dimensional objects with varying contrast, z axis sampling and selection of regions of interest, has not yet been addressed in the literature. This investigation examines these factors.