Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice.
Time-of-day influences on respiratory sequelae following maximal electroshock-induced seizures in mice.
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一天中的时间对小鼠最大电击诱发癫痫发作后呼吸系统后遗症的影响。
DOI：
10.1152/jn.00039.2017
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发表时间：
2017
影响因子：
2.5
通讯作者：
Buchanan,GordonF
中科院分区：
文献类型：
--
作者：
Purnell,BentonS;Hajek,MichaelA;Buchanan,GordonF
癫痫猝死（SUDEP）是难治性癫痫患者死亡的主要原因。虽然SUDEP的具体机制尚未完全了解，但有证据表明，大多数SUDEP的发生是由于呼吸暂停引起的呼吸停止。SUDEP也往往发生在晚上。虽然这可能是由于人类在夜间发现自己的情况，例如在没有监督的情况下独自一人或易于入睡，或者由于睡眠状态的独立影响，但是存在许多原因导致夜间（即，昼夜节律影响）可能是SUDEP的独立危险因素。我们探索了这种可能性。对成年雄性WT小鼠进行EEG、EMG和EKG记录，并在觉醒、非快速眼动（NREM）睡眠和夜间/黑暗阶段的快速眼动（REM）睡眠期间进行最大电休克（MES）癫痫发作。将这些数据与在白天/光照阶段诱导癫痫发作后收集的数据进行比较。夜间诱发的癫痫发作的严重程度和持续时间与白天诱发的癫痫发作相似;然而，夜间诱发的癫痫发作与较低程度的呼吸失调和发作后EEG抑制相关。在夜间快速眼动睡眠期间诱发的癫痫发作普遍是致命的，正如在白天快速眼动睡眠期间诱发的癫痫发作一样。综上所述，这些数据暗示了一天中的时间在影响癫痫发作的生理后果中的作用，这可能导致癫痫引起的死亡。新&值得注意的是癫痫中的意外猝死（SUDEP）是难治性癫痫患者死亡的主要原因。SUDEP经常发生在夜间，这归因于睡眠的影响。我们已经证明，睡眠状态确实影响癫痫发作后的存活率。SUDEP发生在夜间也可能涉及昼夜节律的影响。在这项研究中，我们发现，一天中的时间独立影响癫痫发作的生理后果。
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Although specific mechanisms underlying SUDEP are not well understood, evidence suggests most SUDEP occurs due to seizure-induced respiratory arrest. SUDEP also tends to happen at night. Although this may be due to circumstances in which humans find themselves at night, such as being alone without supervision or sleeping prone, or to independent influences of sleep state, there are a number of reasons why the night (i.e., circadian influences) could be an independent risk factor for SUDEP. We explored this possibility. Adult male WT mice were instrumented for EEG, EMG, and EKG recording and subjected to maximal electroshock (MES) seizures during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep during the nighttime/dark phase. These data were compared with data collected following seizures induced during the daytime/light phase. Seizures induced during the nighttime were similar in severity and duration to those induced during the daytime; however, seizures induced during the nighttime were associated with a lesser degree of respiratory dysregulation and postictal EEG suppression. Seizures induced during REM sleep during the nighttime were universally fatal, as is seen when seizures are induced during REM during the daytime. Taken together, these data implicate a role for time of day in influencing the physiological consequences of seizures that may contribute to seizure-induced death.NEW & NOTEWORTHYSudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. SUDEP frequently occurs during the night, which has been attributed to an effect of sleep. We have shown that sleep state does indeed influence survival following a seizure. That SUDEP occurs during the night could also implicate a circadian influence. In this study we found that time of day independently affects the physiological consequences of seizures.