Clofibrate-induced myopathy in the rat
Clofibrate-induced myopathy in the rat
复制标题
氯贝特诱导的大鼠肌病
作者：
H. Teräväinen;A. Larsen;M. Hillbom
大鼠每日注射氯苯氧异丁酸盐0.2或0.5 g/kg，连续9 ~ 46 d。用光镜和电镜观察小腿肌肉。每天给药0.5 g/kg，连续用药26 ~ 46天，可引起肌病改变。
SummaryRats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy.Daily treatment with 0.5 g/kg of the drug for 26–46 days caused myopathic changes.