Severe Traumatic Head Injury Affects Systemic Cytokine Expression
Severe Traumatic Head Injury Affects Systemic Cytokine Expression
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DOI：
10.1016/j.jamcollsurg.2011.12.015
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发表时间：
2012-04-01
影响因子：
5.2
通讯作者：
Sawyer, Robert G.
中科院分区：
文献类型：
--
作者：
LaPar, Damien J.;Rosenberger, Laura H.;Sawyer, Robert G.
背景：外伤性脑损伤的神经免疫学效应仍然不明确。本研究旨在描述创伤性脑损伤患者的全身细胞因子特征，以评估创伤性脑损伤对全身炎症反应的影响。研究设计：为期5年，从多机构创伤免疫调节数据库中对1022例患者进行评估。根据严重颅脑损伤（SHI；颅脑损伤严重程度评分>= 4,n = 335）与非严重颅脑损伤（NHI；颅脑损伤严重程度评分）对患者进行分层
BACKGROUND: The neuroimmunologic effect of traumatic head injury remains ill-defined. This study aimed to characterize systemic cytokine profiles among traumatically injured patients to assess the effect of traumatic head injury on the systemic inflammatory response.STUDY DESIGN: For 5 years, 1,022 patients were evaluated from a multi-institutional Trauma Immunomodulatory Database. Patients were stratified by presence of severe head injury (SHI; head Injury Severity Score >= 4, n = 335) vs nonsevere head injury (NHI; head Injury Severity Score