Gut Microbiome-Mediated Alteration of Immunity, Inflammation, and Metabolism Involved in the Regulation of Non-alcoholic Fatty Liver Disease.
Gut Microbiome-Mediated Alteration of Immunity, Inflammation, and Metabolism Involved in the Regulation of Non-alcoholic Fatty Liver Disease.
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肠道微生物介导的免疫、炎症和代谢的改变参与非酒精性脂肪肝的调节
DOI：
10.3389/fmicb.2021.761836
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发表时间：
2021
影响因子：
5.2
通讯作者：
Bai XL
中科院分区：
文献类型：
--
作者：
He LH;Yao DH;Wang LY;Zhang L;Bai XL
非酒精性脂肪性肝病（NAFLD）是终末期肝病的主要原因之一，导致全球公共卫生负担迅速增长。术语“肠道微生物组（GM）”是指栖息在宿主胃肠道中的大约100万亿个微生物细胞。越来越多的证据表明GM参与了NAFLD的发病机制，并可能成为潜在的干预靶点。为了探索基于GM的NAFLD精确诊断和治疗策略，已经做出了很大努力来全面深入地了解宿主-微生物相互作用。本文对这种相互作用进行了批判性的评价，主要考虑了疾病发病机制演变过程中代谢、免疫和炎症状态的复杂调节，通过研究潜在机制、诊断和调节策略的进展，揭示了GM在NAFLD中的作用。简介：考虑到复杂的代谢和免疫/炎症稳态调节，我们评估了对宿主-微生物相互作用的最新理解，并揭示了胃肠道微生物组在NAFLD中的作用。提出了针对胃肠道微生物组诊断和治疗NAFLD的策略。
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of end-stage liver disease, leading to a rapidly growing global public health burden. The term “gut microbiome (GM)” refers to the approximately 100 trillion microbial cells that inhabit the host’s gastrointestinal tract. There is increasing evidence that GM is involved in the pathogenesis of NAFLD and may be a potential target for intervention. To explore GM-based strategies for precise diagnosis and treatment of NAFLD, great efforts have been made to develop a comprehensive and in-depth understanding of the host–microbe interaction. This review evaluates this interaction critically, mainly considering the intricate regulation of the metabolism, immunity, and inflammatory status during the evolution of the disease pathogenesis, revealing roles for the GM in NAFLD by examining advances in potential mechanisms, diagnostics, and modulation strategies. Synopsis: Considering the intricate metabolic and immune/inflammatory homeostasis regulation, we evaluate the latest understanding of the host–microbe interaction and reveal roles for the gastrointestinal microbiome in NAFLD. Strategies targeting the gastrointestinal microbiome for the diagnosis and treatment of NAFLD are proposed.
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影响因子：
3.7
作者：
Baker SS;Baker RD;Liu W;Nowak NJ;Zhu L
通讯作者：
Zhu L
DOI：
10.5005/jp-journals-10018-1226
发表时间：
2017-01
期刊：
Euroasian journal of hepato-gastroenterology
影响因子：
--
作者：
Abdel Monem SM
通讯作者：
Abdel Monem SM
影响因子：
0.9
作者：
Cortez-Pinto H;Borralho P;Machado J;Lopes MT;Gato IV;Santos AM;Guerreiro AS
通讯作者：
Guerreiro AS
影响因子：
5.2
作者：
Cani PD;de Vos WM
通讯作者：
de Vos WM
影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.