The effects of systemic medications on ocular blood flow
The effects of systemic medications on ocular blood flow
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DOI：
10.3129/i08-057
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发表时间：
2008-06-01
影响因子：
4.2
通讯作者：
Deschenes, Micheline C.
中科院分区：
文献类型：
--
作者：
Lesk, Mark R.;Wajszilber, Marcelo;Deschenes, Micheline C.
本文综述了全身性药物和一些天然血管活性分子对眼血流（OBF）的影响。一些证据表明，中枢作用钙通道阻滞剂、一氧化氮前体、腺苷、组胺、雌激素和银杏叶提取物具有积极作用，而内皮素-1和吲哚美辛则对OBF具有负面作用。其他一些分子似乎具有混合效应，这取决于所研究的眼血管床或研究方案。此外，医学诱导的全身血压（BP）变化对OBF有重要影响，这种影响的方向和幅度可能取决于患者和眼睛的疾病状态，以及达到的BP绝对水平。关于全身性药物对青光眼患者OBF的影响的研究相对较少，并且对此类治疗对视神经结构和功能的保护的长期影响知之甚少。
This article reviews the effects of systemic medications and some native vasoactive molecules on ocular blood flow (OBF). Some evidence exists for a positive effect of centrally acting calcium-channel blockers, nitric oxide precursors, adenosine, histamine, estrogens, and ginkgo biloba extract, while evidence for a negative effect on OBF exists for endothelin-1 and indomethacin. Some other molecules appear to have mixed effects, depending on the ocular vascular bed studied or the study protocol. In addition, medically induced changes in systemic blood pressure (BP) have an important impact on OBF, and the direction and magnitude of this effect may depend on the disease status of the patient and of the eye, as well as the absolute level of BP achieved. There are relatively few studies of the effects of systemic medications on OBF in glaucoma patients, and little is known of the long-term impact of such therapies on the preservation of optic nerve structure and function.