Serotonin Improves High Fat Diet Induced Obesity in Mice.
Serotonin Improves High Fat Diet Induced Obesity in Mice.
复制标题
血清素可改善高脂肪饮食引起的小鼠肥胖。
DOI：
10.1371/journal.pone.0147143
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Aso H
中科院分区：
文献类型：
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作者：
Watanabe H;Nakano T;Saito R;Akasaka D;Saito K;Ogasawara H;Minashima T;Miyazawa K;Kanaya T;Takakura I;Inoue N;Ikeda I;Chen X;Miyake M;Kitazawa H;Shirakawa H;Sato K;Tahara K;Nagasawa Y;Rose MT;Ohwada S;Watanabe K;Aso H
有两个独立的5-羟色胺（5-HT）组织系统：一个在中枢神经系统，另一个在外周。5-HT影响中枢神经系统的进食行为和肥胖。另一方面，外周5-HT也可能在肥胖中起重要作用，因为已有报道5-HT调节糖和脂质代谢。在这里，我们表明，腹腔注射5-HT小鼠抑制体重增加，高血糖症和胰岛素抵抗，并完全防止扩大的腹腔内脂肪细胞没有任何影响时，对食物的摄入量高脂肪饮食，但不是在普通饲料饮食。5-HT增加能量消耗、O2消耗和CO2产生。外周5-HT的这种新的代谢作用与比目鱼肌中肌纤维类型从快速/糖酵解到缓慢/氧化的转变密切相关。此外，5-HT还显著诱导比目鱼肌过氧化物酶体增殖物激活受体辅激活因子1α（PGC-1α）-B和PGC-1α-c的mRNA表达增加。5-HT受体（5 HTR）2A或7种拮抗剂可抑制5-HT注射引起的上述基因mRNA表达的升高。我们的研究结果表明，外周5-HT可能通过加速骨骼肌的能量消耗在缓解肥胖和其他代谢紊乱中发挥重要作用。
There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.