The emergence of Schmallenberg virus across Culicoides communities and ecosystems in Europe
The emergence of Schmallenberg virus across Culicoides communities and ecosystems in Europe
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DOI：
10.1016/j.prevetmed.2014.03.007
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发表时间：
2014-10-15
影响因子：
2.6
通讯作者：
Garros, Claire
中科院分区：
文献类型：
--
作者：
Balenghien, Thomas;Pages, Nonito;Garros, Claire
Schmallenberg病毒（SBV）是一种新型虫媒病毒病原体，自2011年以来在欧洲出现并传播，使受感染成年反刍动物的后代发生先天性畸形。通过在北方欧洲进行的研究，几种库蠓（双翅目：蠓科）与SBV的传播有关。在这项研究中，从法国大陆和意大利（撒丁岛）的SBV爆发地区的库蠓进行了病毒RNA的筛选。两者的作用C。obsoletus和Obsoletus复合体（C. obsoletus和C. scoticus）传播SBV，并在法国的一个C. nubeculosus的第一次，暗示这个物种作为一个潜在的载体。撒丁岛的采集以C.除了这些基于现场的研究外，在C. imicola的群体中，仅检测到相对少量的SBV RNA，需要其在传播中的潜在作用的确凿证据。nubeculosus和野外采集的C.在实验室中也对scoticus进行了检查。C. nubeculosus低，证实了以前的研究，而初步检查C。scoticus证明，虽然该物种可以复制SBV到潜在的传播水平，但需要进一步的工作来充分确定该地区物种之间的比较能力。最后，在实验室中的两个丰富和广泛的蚊子媒介物种的SBV的口腔能力进行了评估。无论是白纹伊蚊还是尖音库蚊都没有被证明能将SBV复制到可传播的水平，而且似乎不太可能在传播中发挥主要作用。然后全面审查了迄今为止从欧洲各地的研究中产生的其他媒介能力数据，并与以前产生的蓝舌病病毒进行了比较。(C)© 2014 Elsevier B.V.保留所有权利。
Schmallenberg virus (SBV), a novel arboviral pathogen, has emerged and spread across Europe since 2011 inflicting congenital deformities in the offspring of infected adult ruminants. Several species of Culicoides biting midges (Diptera: Ceratopogonidae) have been implicated in the transmission of SBV through studies conducted in northern Europe. In this study Culicoides from SBV outbreak areas of mainland France and Italy (Sardinia) were screened for viral RNA. The role of both C. obsoletus and the Obsoletus complex (C. obsoletus and C. scoticus) in transmission of SBV were confirmed in France and SBV was also discovered in a pool of C. nubeculosus for the first time, implicating this species as a potential vector. While collections in Sardinia were dominated by C. imicola, only relatively small quantities of SBV RNA were detected in pools of this species and conclusive evidence of its potential role in transmission is required.In addition to these field-based studies, infection rates in colony-derived individuals of C. nubeculosus and field-collected C. scoticus are also examined in the laboratory. Rates of infection in C. nubeculosus were low, confirming previous studies, while preliminary examination of C. scoticus demonstrated that while this species can replicate SBV to a potentially transmissible level, further work is required to fully define comparative competence between species in the region. Finally, the oral competence for SBV of two abundant and widespread mosquito vector species in the laboratory is assessed. Neither Aedes albopictus nor Culex pipiens were demonstrated to replicate SBV to transmissible levels and appear unlikely to play a major role in transmission. Other vector competence data produced from studies across Europe to date is then comprehensively reviewed and compared with that generated previously for bluetongue virus. (C) 2014 Elsevier B.V. All rights reserved.