Perioperative Red Blood Cell Transfusion Is Associated with Poor Long-term Survival in Pancreatic Adenocarcinoma
Perioperative Red Blood Cell Transfusion Is Associated with Poor Long-term Survival in Pancreatic Adenocarcinoma
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DOI：
10.21873/anticanres.12031
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发表时间：
2017-10-01
影响因子：
2
通讯作者：
Noriyuki, Toshio
中科院分区：
文献类型：
--
作者：
Abe, Tomoyuki;Amano, Hironobu;Noriyuki, Toshio
背景/目的：围手术期红细胞输注（RBCT）会对宿主的免疫系统产生负面影响。我们研究了围手术期RBCT对胰腺导管腺癌（PDAC）患者长期生存的影响。患者和方法：我们回顾性评估了148例接受手术治疗的PDAC患者（33例接受RBCT，115例未接受）。采用考克斯比例风险回归模型对单变量分析的重要预后变量进行多变量分析。结果如下：两组在年龄、术前血红蛋白水平、碳水化合物抗原19-9水平、最大肿瘤大小、肿瘤分期、手术时间、术中失血量、大血管切除率和胰十二指肠切除率方面存在显著差异。接受RBCT的患者总体生存率明显较差（p
Background/Aim: Perioperative red blood cell transfusion (RBCT) can negatively affect the host's immune system. We investigated the effects of perioperative RBCT on long-term survival among patients with pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: We retrospectively evaluated 148 patients with PDAC who underwent surgery with curative intent (33 who received RBCTs and 115 who did not). Significant prognostic variables on univariate analysis were subjected to multivariate analyses using a Cox proportional hazard regression model. Results: Both groups exhibited significant differences in age, preoperative haemoglobin levels, carbohydrate antigen 19-9 levels, maximum tumour size, tumour staging, operative time, intraoperative blood loss, major vascular resection, and the proportion of pancreaticoduodenectomies performed. Patients who underwent RBCTs exhibited significantly poorer overall survival (p