Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls
Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls
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DOI：
10.1111/acps.12467
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发表时间：
2016-01-01
影响因子：
6.7
通讯作者：
Andreassen, O. A.
中科院分区：
文献类型：
--
作者：
Hoseth, E. Z.;Westlye, L. T.;Andreassen, O. A.
目的：研究严重精神疾病患者和健康对照者血浆免疫标志物水平升高是否与言语记忆和海马体亚区体积相关。方法：共招募了230名DSM-IV型精神分裂症或双相情感障碍患者和236名健康对照者。采用韦氏记忆量表第三版（WMS-III）对记忆进行评估，采用逻辑记忆即时记忆和延迟记忆，采用加州语言学习测验对学习列表记忆（CVLT学习）和延迟自由记忆进行总结。我们测量了血浆可溶性肿瘤坏死因子受体1 （sTNF-R1）、白细胞介素-1受体拮抗剂、白细胞介素-6、血管性血友病因子、骨保护素、高敏c反应蛋白和sCD40配体的水平。使用FreeSurfer获得海马子场估计。结果：在控制了年龄、性别和诊断后，我们发现sTNF-R1与WMS-III逻辑记忆测试测量的言语记忆学习和回忆测试的表现之间存在中度负相关。我们没有观察到诊断和sTNF-R1对记忆评分的交互作用。我们还发现CVLT学习和海马体积之间名义上显著的正相关。结论：研究结果表明免疫参与记忆的作用独立于严重的精神障碍，并可能支持海马体子区体积“越大越好”的假设。
Objective: We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients with severe mental illnesses and in healthy controls.Method: In total, 230 patients with a broad DSM-IV schizophrenia spectrum illness or bipolar disorder and 236 healthy controls were recruited. Memory was assessed using the Wechsler Memory Scale Third Edition (WMS-III) Logical Memory immediate and delayed recall, and the California Verbal Learning Test summed recall over learning list (CVLT learning) and delayed free recall. We measured plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist, interleukin-6, von Willebrand factor, osteoprotegerin, high-sensitivity C-reactive protein and sCD40 ligand. Hippocampal subfield estimates were obtained using FreeSurfer.Results: We found a moderate negative association between sTNF-R1 and performance on verbal memory learning and recall tests as measured by the WMS-III Logical Memory after controlling for age, sex and diagnosis. We observed no interaction effect of diagnosis and sTNF-R1 on memory scores. We also found a nominally significant positive association between CVLT learning and hippocampal volumes.Conclusion: The findings suggest a role for immune involvement in memory independent of severe mental disorders and may support the `bigger is better' hypothesis of hippocampal subfield volumes.