Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats
Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats
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DOI：
10.1016/j.reprotox.2004.05.005
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Ropstad, E
中科院分区：
文献类型：
--
作者：
Lyche, JL;Oskam, IC;Ropstad, E
本研究的目的是调查PCB 153和PCB 126的环境剂量是否会在受控动物模型中产生影响。通过测量妊娠期和哺乳期暴露的山羊幼仔的促性腺激素和性腺类固醇激素浓度，检查了对下丘脑-垂体-性腺轴可能产生的不良影响。产后9个月山羊仔脂肪组织中PCB 153和PCB 126的浓度分别为5800 ng/g（脂重，范围; 2900-12700 ng/g）和0.49 ng/g（脂重，范围; 0.28-0.80 ng/g）。分析了青春期前后血浆促黄体生成素（LH）、促卵泡激素（FSH）、催乳素（Prl）和孕酮（P4）的浓度。LH，FSH，Prl和P4也在诱导的发情周期中测量。暴露于PCB 153组的青春期前LH浓度显著降低，青春期延迟，发情周期黄体期P4水平较高。PCB 153暴露对Prl和FSH无显著影响。PCB 126在本研究测试的暴露水平下不会产生任何影响。因此，围产期暴露于PCB 153对山羊的生殖功能和青春期发育有一定的影响。(C)2004年爱思唯尔公司All rights reserved.
The aim of the present study was to investigate if environmental doses of PCB 153 and PCB 126 could produce effects in a controlled animal model. Possible adverse effects on the hypothalamic-pitutitary-gonadal axis were examined by measuring gonadotrophins and gonadal steroid hormone concentrations in goat kids exposed during gestation and lactation. The concentrations of PCB 153 and PCB 126 in adipose tissue in the goat kids 9 months post-partum were 5800 ng/g (fat-weight, range; 2900-12700 ng/g) and 0.49 ng/g (fat-weight, range; 0.28-0.80 ng/g), respectively. The pre- and post-pubertal plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (Prl) and progesterone (P4) were analysed. LH, FSH, Prl, and P4 were also measured during an induced oestrus cycle. The prepubertal LH concentration was significantly lower, the puberty was delayed and the P4 level during the luteal phase of an estrous cycle was higher in the group exposed to PCB 153. No significant effect of PCB 153 exposure was found on Prl and FSH. PCB 126 did not produce any effects at the exposure level tested in this study. In conclusion, perinatal exposure to PCB 153 affected the reproductive function and the puberty maturation in goats. (C) 2004 Elsevier Inc. All rights reserved.