Hereditary hemochromatosis and risk of ischemic heart disease -: A prospective study and a case-control study
Hereditary hemochromatosis and risk of ischemic heart disease -: A prospective study and a case-control study
复制标题
DOI：
10.1161/circulationaha.104.496075
复制
发表时间：
2005-07-12
期刊：
影响因子：
37.8
通讯作者：
Nordestgaard, BG
中科院分区：
文献类型：
--
作者：
Ellervik, C;Tybjærg- Hansen, A;Nordestgaard, BG
背景-我们检验了遗传性血色病基因型C282 Y/C282 Y、C282 Y/H63 D或C282 Y/野生型是缺血性心脏病（IHD）和心肌梗死（MI）的危险因素的假设。方法和结果-我们对来自丹麦普通人群的9178名个体进行了前瞻性研究，随访24年，在此期间，分别有1035和511人发展为IHD和MI，以及2441和1113例IHD和MI病例与8080例对照的病例对照研究。在前瞻性研究中，C282 Y/C282 Y、C282 Y/H63 D和C282 Y/野生型个体与野生型/野生型个体相比，总体或按性别分层，与IHD或MI风险增加无关。我们有90%的把握度来检测C282 Y/C282 Y、C282 Y/H63 D和C282 Y/野生型与野生型/野生型的IHD风险比，C282 Y/C282 Y、C282 Y/H63 D和C282 Y/野生型分别为3.4、1.9和1.3。此外，在病例对照研究中，无论是总体还是按性别分层，这些基因型与IHD或MI的风险增加无关。我们有90%的能力检测出C282 Y/C282 Y、C282 Y/H63 D和C282 Y/野生型与野生型/wild-type.Conclusions相比IHD的优势比为3.6、1.8和1.3。然而，该研究缺乏排除C282 Y/C282 Y和C282 Y/H63 D个体具有适度增加的IHD或MI风险的可能性的能力。
Background - We tested the hypothesis that the hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, or C282Y/wild-type are risk factors for ischemic heart disease (IHD) and myocardial infarction (MI).Methods and Results - We performed a prospective study of 9178 individuals from the Danish general population followed up for 24 years, during which 1035 and 511 developed IHD and MI, respectively, and a case-control study of 2441 and 1113 IHD and MI cases versus 8080 controls. C282Y/C282Y, C282Y/H63D, and C282Y/wild-type versus wild-type/wild-type individuals were not associated with increased risk of IHD or MI in prospective studies, overall or stratified by gender. We had 90% power to detect a hazard ratio for IHD of 3.4 for C282Y/C282Y, 1.9 for C282Y/H63D, and 1.3 for C282Y/wild-type versus wild-type/wild-type. Furthermore, these genotypes were not associated with increased risk of IHD or MI in case-control studies, overall or stratified by gender. We had 90% power to detect an odds ratio for IHD of 3.6 for C282Y/C282Y, 1.8 for C282Y/H63D, and 1.3 for C282Y/wild-type versus wild-type/wild-type.Conclusions - In these studies, hereditary hemochromatosis C282Y/C282Y, C282Y/H63D, and C282Y/wild-type genotypes were not associated with IHD or MI; however, the study lacked the power to exclude the possibility that C282Y/C282Y and C282Y/H63D individuals have a modestly increased risk of IHD or MI.