Intracellular mechanisms in control of acid secretion
Intracellular mechanisms in control of acid secretion
复制标题
控制酸分泌的细胞内机制
DOI：
10.1097/00001574-199112000-00004
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
C. Chew
中科院分区：
文献类型：
--
作者：
C. Chew
本综述考虑了过去 12 个月在阐明控制胃壁细胞盐酸分泌的细胞机制方面取得的进展。在酸分泌抑制剂的临床相关作用的背景下，检查刺激性激动剂、组胺、乙酰胆碱和胃泌素以及分泌抑制剂、前列腺素、生长抑素和表皮生长因子的作用。还讨论了胃 H+、K+-ATP 酶（质子泵）的最新分子特征。
This review considers progress over the past 12 months in the elucidation of cellular mechanisms controlling gastric parietal cell hydrochloric acid secretion. The actions of the stimulatory agonists, histamine, acetylcholine, and gastrin and the secretory inhibitors, prostaglandins, somatostatin, and epidermal growth factor, are examined against a backdrop of clinically relevant actions of acid secretory inhibitors. Recent molecular characterizations of the gastric H+, K+-ATPase (proton pump) are also discussed.