Expression of fatty acid synthase (FASN) in oral nevi and melanoma
Expression of fatty acid synthase (FASN) in oral nevi and melanoma
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DOI：
10.1111/j.1601-0825.2011.01841.x
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发表时间：
2011-11-01
期刊：
影响因子：
3.8
通讯作者：
de Almeida, O. P.
中科院分区：
文献类型：
--
作者：
de Andrade, B. A. B.;Leon, J. E.;de Almeida, O. P.
目的：本研究的目的是确定脂肪酸合成酶（FASN）在口腔痣和黑色素瘤中的表达，并将结果与相应的皮肤病变进行比较。材料和方法：通过免疫组织化学方法评价了51个口腔黑色素细胞病变（包括38个粘膜内痣和13个原发性口腔黑色素瘤）、10个皮肤痣和14个黑色素瘤中FASN的表达。结果：脂肪酸合成酶仅在口腔粘膜或皮肤黑色素瘤中强烈表达。另一方面，大多数口腔和皮肤痣呈阴性，少数口腔病例呈局灶性和弱表达。结论：脂肪酸合成酶在口腔恶性黑素细胞中有表达，可作为口腔黑素细胞痣与口腔黑素细胞痣鉴别诊断的一个有用标志物。口腔疾病（2011）17，808-812
OBJECTIVE: The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.MATERIALS AND METHODS: Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas.RESULTS: Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression.CONCLUSION: Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi. Oral Diseases (2011) 17, 808-812