Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats
Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats
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DOI：
10.1007/s00702-007-0627-6
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Reynolds, G. P.
中科院分区：
文献类型：
--
作者：
Harte, M. K.;Powell, S. B.;Reynolds, G. P.
尸检研究为精神分裂症患者的γ-氨基丁酸（GABA）能系统异常提供了证据。钙结合蛋白（CBP）、小清蛋白（PV）、钙结合蛋白（CB）和钙视网膜蛋白（CR）可用作大脑中特定GABA能神经元亚群的标记物。大鼠的隔离饲养是一种非药理学的，非损伤操作导致惊吓反射（PPI）前脉冲抑制缺陷以及其他行为和神经化学变化，使人联想到精神分裂症。雌性大鼠在社会住房（三组）或单独饲养11周后断奶，并测量PPI。与社会圈养的大鼠相比，隔离大鼠表现出PPI缺陷和减少在海马中的PV和CB免疫反应细胞，CR没有显着变化。这些发现表明，隔离饲养大鼠海马中GABA能中间神经元亚群的选择性异常，类似于精神分裂症中该区域的神经元缺陷。
Post-mortem studies have provided evidence for abnormalities of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia. The calcium-binding proteins (CBPs), parvalbumin (PV), calbindin (CB) and calretinin (CR) can be used as markers for specific subpopulations of GABAergic neurons in the brain.Isolation rearing of rats is a non-pharmacological, non-lesion manipulation that leads to deficits in prepulse inhibition of the startle reflex (PPI) and other behavioural and neurochemical alterations reminiscent of schizophrenia.Female rats were reared in social housing (groups of three) or singly for 11 weeks post weaning and PPI was measured. Brains were removed and hippocampal CBP - containing neurons determined following immunocytochemical staining.Compared to socially housed rats, isolated rats exhibited PPI deficits and reductions in PV and CB-immunoreactive cells in the hippocampus, with no significant change in CR. These findings demonstrate selective abnormalities of sub-populations of GABAergic interneurons in the hippocampus of isolation reared rats, which resemble the neuronal deficits seen in this region in schizophrenia.