Serum superoxide dismutase activity correlates with the components of metabolic syndrome or carotid artery intima-media thickness
Serum superoxide dismutase activity correlates with the components of metabolic syndrome or carotid artery intima-media thickness
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DOI：
10.1016/j.diabres.2009.09.007
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发表时间：
2009-12-01
影响因子：
5.1
通讯作者：
Shiba, Teruo
中科院分区：
文献类型：
--
作者：
Isogawa, Akihiro;Yamakado, Minoru;Shiba, Teruo
消除活性氧的酶的活性阻止了动脉粥样硬化的进展。我们对3234例接受全面健康体检的人群进行了横断面研究，研究了血清超氧化物歧化酶（SOD）活性与动脉粥样硬化或颈动脉内膜-中膜厚度（IMT）危险因素的关系。血清SOD活性与体重指数（BMI）、收缩压和舒张压、血清甘油三酯（TG）浓度和血清葡萄糖浓度呈负相关。血清SOD活性低与颈动脉IMT增厚呈正相关。但另一方面，颈动脉斑块的存在与血清SOD活性呈正相关，尤其是男性。血清SOD活性与代谢综合征各组分呈负相关，血清SOD活性低似乎是颈动脉IMT增厚的独立危险因素。另一方面，血清SOD活性水平似乎有限地升高，但对氧化应激（如颈动脉斑块形成）增加的状态具有反应性。2009爱思唯尔爱尔兰有限公司版权所有。
The activities of the enzymes to eliminate reactive oxygen species prevent the progression of atherosclerosis. We conducted a cross-sectional study among 3234 people that underwent total health check-up service, and studied the relationship between the serum superoxide dismutase (SOD) activity and risk factors of atherosclerosis or carotid artery intima-media thickness (IMT). Serum SOD activity negatively correlated with body mass index (BMI), systolic and diastolic blood pressure, serum triglyceride (TG) concentration and serum glucose concentration. Low serum SOD activity positively correlated with the carotid IMT thickening. But on the other hand, existence of carotid artery plaque positively correlated with serum SOD activity especially among men. Serum SOD activity negatively correlated with the components of metabolic syndrome and low serum SOD activity seems to be an independent risk of the thickening of carotid IMT. On the other hand, serum SOD activity level seems to elevate limitedly but reactively to the status of increased oxidative stress, such as carotid plaque formation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.