Competitive interactions between sponge-associated bacteria
Competitive interactions between sponge-associated bacteria
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DOI：
10.1093/femsec/fix008
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发表时间：
2017-03-01
影响因子：
4.2
通讯作者：
Thomas, Torsten
中科院分区：
文献类型：
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作者：
Esteves, Ana I. S.;Cullen, Alescia;Thomas, Torsten
与海洋海绵相关的微生物群落的多样性已经得到了广泛的研究，但它们在海绵全息生物中的功能和相互作用直到最近才得到重视。众所周知，海绵相关微生物可以产生一系列具有生物技术应用的抑制性代谢物，但这些化合物的生态作用仍然难以捉摸。在这项工作中，我们探讨了培养的海绵相关细菌之间的竞争相互作用，以检查产生抗菌活性的细菌是否能够抑制潜在的致病菌。我们分离出一种具有海绵降解活性的芽孢杆菌，这种细菌可能对宿主有负面影响。这种细菌以及从同一属中分离出来的其他海绵细菌，被一种密切相关的海绵衍生假弧菌亚群所抑制。在一些假弧菌菌株中，这种抑制活性与产生多酮的遗传能力有关，如红素内酯。我们的观察表明，拮抗活性可能影响海绵微生物组的组成，包括可能对宿主有害的细菌的丰度。
The diversity of the microbial communities associated with marine sponges has been extensively studied, but their functioning and interactions within the sponge holobiont are only recently being appreciated. Sponge-associated microorganisms are known for the production of a range of inhibitory metabolites with biotechnological application, but the ecological role that these compounds remains elusive. In this work, we explore the competitive interactions between cultivated sponge-associated bacteria to inspect whether bacteria that produce antimicrobial activities are able to inhibit potentially pathogenic bacteria. We isolated a Bacillus sp. bacterium with sponge-degrading activity, which likely has a negative impact on the host. This bacterium, along with other sponge isolates from the same genus, was found to be inhibited by a subpopulation of closely related sponge-derived Pseudovibrio spp. In some Pseudovibrio strains, these inhibitory activities were correlated with the genetic capacity to produce polyketides, such as erythronolide. Our observations suggest that antagonistic activities likely influence the composition of the sponge microbiome, including the abundance of bacteria that can be harmful to the host.