Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C
Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C
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DOI：
10.1053/gast.2002.33588
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发表时间：
2002-06-01
期刊：
影响因子：
29.4
通讯作者：
Lok, ASF
中科院分区：
文献类型：
--
作者：
Chu, CJ;Hussain, M;Lok, ASF
背景与目的：最近的研究表明，与C基因相比，B基因与肝脏疾病的活动性较差。我们的研究目的是确定与C基因相比，B基因是否与较高的自发乙肝e抗原(HBeAg)转换率相关。采用线探针法对332例慢性乙肝患者的血清标本进行了基因分型，平均随访48个月。结果：273例患者中检出HBVDNA，其中B型122例，C型147例。B型患者发病时HBeAg感染率显著降低，随访期间HBeAg自发转换率显著升高。与HBeAg阳性的HBVB型患者相比，HBeAg阳性的HBVB型患者明显年轻，而且自发性HBeAg血清转换发生的时间比HBVC型患者早约10年。多变量分析发现，高丙氨酸氨基转移酶(基线和随访)、年龄和30岁以及B型是与自发性HBeAg血清转换相关的独立因素。结论：与C型相比，B型乙肝病毒与HBeAg血清转换的时间较早，这一发现可能解释了B型患者的肝病不太活跃/进展性较差的原因。
Background & Aims: Recent studies suggest that hepatitis B virus (HBV) genotype B Is associated with less active liver disease than HBV genotype C. The aim of our study was to determine If HBV genotype B Is associated with higher rates of spontaneous hepatitis B e antigen (HBeAg) seroconversion compared with genotype C. Methods. A retrospective study using stored sera from 332 Chinese patients with chronic HBV Infection followed for a mean of 48 months (range, 12-98) were tested for HBV genotype using a line-probe assay. Results: HBV DNA was detected In 273 patients, 122 had HBV genotype B and 147 genotype C. Patients with genotype B had a significantly lower prevalence of HBeAg at presentation and significantly higher rates of spontaneous HBeAg seroconversion during follow-up. HBV genotype B patients who were HBeAg positive were significantly younger, and spontaneous HBeAg seroconversion occurred approximately 1 decade earlier compared with HBV genotype C patients. Multivariate analyses identified high alanine aminotransferase (baseline and follow-up), age >30 years, and genotype B as Independent factors associated with spontaneous HBeAg seroconversion. Conclusions: HBV genotype B Is associated with earlier HBeAg seroconversion than genotype C. This finding may explain the less active/progressive liver disease In patients with genotype B.