Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia.
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia.
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DOI：
10.1513/annalsats.201308-261cr
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发表时间：
2014-01-01
影响因子：
8.3
通讯作者：
Henke, David C
中科院分区：
文献类型：
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作者：
Pathak, Vikas;Kuhn, Judy M;Henke, David C
隐源性机化性肺炎是机化性肺炎的一种特发性形式(也称为闭塞性细支气管炎机化性肺炎)。由于隐源性机化性肺炎被认为是一种炎症性疾病，它对广谱抗炎皮质类固醇激素有典型的反应，尽管停止使用后复发很常见。此外，长期使用皮质类固醇有许多副作用。在皮质类固醇无效的严重病例中，要么使用细胞毒治疗，要么使用大环内酯类治疗。由于细胞毒性治疗(如环磷酰胺)的毒性和不良反应，这种治疗方案不能长期用于难治性病例。大环内酯类药物已被证明是一种有效的抗炎药，长期用于隐源性机化性肺炎患者是相对安全的。
Cryptogenic organizing pneumonia is an idiopathic form of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia). Because cryptogenic organizing pneumonia is considered an inflammatory disease, it characteristically responds to the broad-spectrum antiinflammatory corticosteroids, although relapse is common on discontinued use. Additionally, long-term use of corticosteroids has many side effects. In severe cases in which corticosteroids have failed, either cytotoxic therapy or macrolide therapy is used. Because of the toxicity and adverse effects of cytotoxic therapy (e.g., cyclophosphamide), this therapy option cannot be used long term in refractory cases. Macrolide therapy has been shown to be an effective antiinflammatory agent that is relatively safe when used on a long-term basis in patients with cryptogenic organizing pneumonia.