Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
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DOI：
10.1016/0304-3835(87)90156-x
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发表时间：
1987-10
期刊：
影响因子：
9.7
通讯作者：
D. Mccormick;A. M. Spicer
中科院分区：
文献类型：
--
作者：
D. Mccormick;A. M. Spicer
测定了脂肪氧合酶抑制剂去甲二氢愈创木酸(NDGA)在大鼠乳腺中的抗癌活性。从单次静脉注射后1周开始。雌性SD大鼠体重为20或50 mg-甲基-N-亚硝脲(MNU)/kg体重，饲喂添加0或1000 mg/kg NDGA的半纯饲料。在两个MNU剂量水平下，接受NDGA的小组患乳腺癌的比例明显低于饮食对照组；NDGA没有引起任何肉眼或器官特异性毒性。这些数据表明脂氧合酶产物参与了乳腺癌的诱发过程，并为化学预防药物的设计提供了额外的酶靶点。
The activity of the lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA), as a cancer chemopreventive agent in the rat mammary gland was determined. Beginning 1 week after a single i.v. dose of 20 or 50 mgN-methyl-N-nitrosourea (MNU)/kg body wt., female Sprague-Dawley rats were fed a semi-purified diet supplemented with 0 or 1000 mg NDGA/kg diet. At both MNU dose levels, groups receiving NDGA developed significantly fewer mammary cancers than did dietary controls; NDGA induced no gross or organ-specific toxicity. These data implicate lipoxygenase products in the process of mammary cancer induction, and suggest and additional enzymatic target for the design of chemopreventive drugs.