The role of gastrointestinal hormones in the pathogenesis of obesity and type 2 diabetes.
The role of gastrointestinal hormones in the pathogenesis of obesity and type 2 diabetes.
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DOI：
10.5114/pg.2014.42498
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发表时间：
2014
影响因子：
--
通讯作者：
Krętowski A
中科院分区：
文献类型：
--
作者：
Adamska E;Ostrowska L;Górska M;Krętowski A
肥胖是一个日益严重的世界性医学问题，它影响着2型糖尿病、心血管并发症和癌症发病率的增加。饥饿感和饱腹感由“肠-脑轴”刺激，其中胃肠激素发挥关键作用：胰高血糖素样肽1、葡萄糖依赖性促胰岛素多肽、胰多肽、肽YY、胃泌酸调节素、胆囊收缩素和胃饥饿素。这些激素不仅影响消化道的功能，而且可能对胰岛素分泌有影响，并且是影响参与调节食物摄入的大脑区域的介质。它们的作用效果可以是拮抗的，也可以是相加的或协同的，它们的分泌取决于许多因素，例如膳食营养素或身体的能量状态。循环肠道激素浓度的变化导致主要在下丘脑和脑干区域内的各种途径的激活，这些途径调节进食行为和许多代谢过程。
Obesity, influencing the increase of incidence of type 2 diabetes, cardiovascular complications and cancer is a growing medical problem worldwide. The feelings of hunger and satiety are stimulated by the “gut-brain axis”, where a crucial role is played by gastrointestinal hormones: glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide, pancreatic polypeptide, peptide YY, oxyntomodulin, cholecystokinin and ghrelin. These hormones affect not only the functioning of the digestive tract, but also might have effects on insulin secretion and are mediators which affect brain areas involved in the regulation of food intake. The effect of their actions can be antagonistic as well as an additive or synergistic, and their secretion is dependent on many factors, such as dietary nutrients or the energy state of the body. Changes in circulating gut hormones concentrations result in activation of various pathways primarily within the hypothalamus and brain stem areas, which modulate feeding behaviour and a number of metabolic processes.