Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System
Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System
复制标题
DOI：
10.1523/jneurosci.2429-08.2008
复制
发表时间：
2008-10-22
影响因子：
5.3
通讯作者：
Van Minnen, Jan
中科院分区：
文献类型：
--
作者：
Court, Felipe A.;Hendriks, William T. J.;Van Minnen, Jan
雪旺细胞在周围神经系统的发育和维持中发挥着关键作用。在这里，我们发现，小鼠完整的坐骨神经轴突含有少量核糖体，当轴突去体化（与细胞体分离）时，核糖体数量会增加几个数量级。我们进一步证明，使用华勒变性慢鼠作为模型，施万细胞将多核糖体转移到去体化的轴突。这些数据表明雪旺细胞具有通过在局部提供核糖体来控制轴突蛋白质合成的倾向。
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.