Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (ICDD).
Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (ICDD).
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2,3,7,8-四氯二苯并-对二恶英 (ICDD) 诱导 DT-心肌黄酶。
DOI：
10.1016/0006-291x(76)90029-2
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发表时间：
1976
影响因子：
3.1
通讯作者：
R. A. Neal
中科院分区：
文献类型：
--
作者：
P. Beatty;R. A. Neal
摘要化合物3-甲基胆蒽（3-MC）和2，3，7，8-四氯二苯并二恶英（TCDD）都是芳香烃羟化酶的诱导剂。最近有报道3-MC也是大鼠肝脏DT-黄递酶活性的诱导剂。在这份报告中，TCDD诱导肝DT-心肌黄酶活性的能力进行了检查。结果表明，TCDD作为DT-心肌黄酶活性诱导剂的效力比3-MC高约17，000倍。
Abstract The compounds 3-methylcholanthrene (3-MC) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) are both inducers of the enzyme system aryl hydrocarbon hydroxylase. It has recently been reported that 3-MC is also an inducer of DT-diaphorase activity in rat liver. In this report the ability of TCDD to induce hepatic DT-diaphorase activity was examined. The results indicate that TCDD is approximately 17,000 times more potent as an inducer of DT-diaphorase activity than 3-MC.