Vitamin D and innate immunity
Vitamin D and innate immunity
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DOI：
10.1111/j.1529-8019.2009.01287.x
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Gallo, Richard L.
中科院分区：
文献类型：
--
作者：
Miller, Jeremiah;Gallo, Richard L.
维生素D在骨骼健康中的作用已经得到很好的证实。最近，研究已经确定了维生素D在免疫系统，心血管系统和癌症预防中的其他作用。维生素D对免疫系统的影响与皮肤科医生特别相关，因为它对特应性皮炎，牛皮癣和皮肤癌有影响。然而，对于安全有效的维生素D剂量存在很大分歧，因为紫外线照射和某些富含维生素D的食物都会带来不必要的后果。本综述旨在更新皮肤科医生对维生素D在免疫系统中的作用，不同来源的安全性和剂量，以及可能需要补充的维生素D缺乏症的风险因素。维生素D状态的免疫后果代表了一个额外的方面，说明了如何需要补充指南，并且只有在经过验证的对照临床试验的背景下才能在临床上有用。
Vitamin D's role in bone health has been well established. Recently, studies have identified additional roles of vitamin D in the immune system, cardiovascular system, and cancer prevention. The effect of vitamin D on the immune system is particularly relevant to the dermatologist in that it has implications for atopic dermatitis, psoriasis, and skin cancer. However, there is much disagreement on a dose of vitamin D that is both safe and effective as both ultraviolet exposure and certain vitamin D-rich foods come with unwanted consequences. This review aims to update the dermatologist on the roles of vitamin D in the immune system, the safety and dose of different sources, and risk factors for vitamin D deficiency that may necessitate supplementation. Immune consequences of vitamin D status represent one additional aspect that illustrates how guidelines for supplementation are needed and will only be useful clinically if they are presented in context with validated controlled clinical trials.