TGF-beta: a balancing act.
TGF-beta: a balancing act.
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DOI：
10.3109/08830189809043009
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发表时间：
1998-01-01
影响因子：
5
通讯作者：
Wahl, S M
中科院分区：
文献类型：
--
作者：
McCartney-Francis, N L;Frazier-Jessen, M;Wahl, S M
发育过程以及宿主防御和修复机制的调节需要维持正负调节信号的微妙平衡。 TGF-β 是一种以其多种活性而闻名的分子，可以促进或抑制细胞生长和功能。这些相反活动之间的平衡被破坏可能导致异常发育、恶性肿瘤或致病性免疫和炎症反应。 TGF-β 转基因小鼠研究强调了 TGF-β 及其受体的基本功能，并为操纵 TGF-β 表达的潜在治疗方法提供了见解。
Regulation of developmental processes as well as host defense and repair mechanisms requires the maintenance of a delicate balance of positive and negative regulatory signals. TGF-beta, a molecule known for its many diverse activities, can promote or inhibit cell growth and function. Disruption of the balance between these opposing activities can contribute to aberrant development, malignancy, or pathogenic immune and inflammatory responses. TGF-beta transgenic mouse studies highlight the essential function(s) of TGF-beta and its receptors and provide insight to potential therapeutic approaches to manipulate TGF-beta expression.