RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT
RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT
复制标题
RASSF4促进EV71复制加速抑制AKT磷酸化
DOI：
10.1016/j.bbrc.2015.02.035
复制
发表时间：
2015
影响因子：
3.1
通讯作者：
Liu Wanhong
中科院分区：
文献类型：
--
作者：
Zhang Fengfeng;Liu Yongjuan;Chen Xiong;Dong Lanlan;Zhou Bingfei;Cheng Qingqing;Han Song;Liu Zhongchun;Peng Biwen;He Xiaohua;Liu Wanhong
肠道病毒71型（EV71）是一种嗜神经病毒，可引起手足口病（HFMD），偶尔会导致死亡。RASSF4是RAS相关结构域家族（RASSFs）的成员之一，在细胞死亡、肿瘤发生和信号转导中起重要作用。然而，关于RASSF4和EV71之间的关系知之甚少。我们的研究首次揭示了RASSF4促进EV71复制，然后加速EV71感染的293T细胞中AKT磷酸化抑制，这表明RASSF4可能是设计预防和控制EV71感染的治疗措施的潜在新靶点。
Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.