An fNIRS exploratory investigation of the cortical activity during gait in children with spastic diplegic cerebral palsy.
An fNIRS exploratory investigation of the cortical activity during gait in children with spastic diplegic cerebral palsy.
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DOI：
10.1016/j.braindev.2014.01.003
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发表时间：
2014-11
影响因子：
1.7
通讯作者：
Arpin, David J.
中科院分区：
文献类型：
--
作者：
Kurz, Max J.;Wilson, Tony W.;Arpin, David J.
这项探索性研究的主要目的是确定痉挛型双瘫脑瘫（CP）儿童和典型发育儿童在步态中的皮层激活是否存在差异。采用功能近红外光谱法检测儿童在跑步机上行走时辅助运动区、中央前回、中央后回和上级顶叶中氧合血红蛋白的浓度。同时收集矢状面视频，随后进行数字化以量化时间步态变化。1)CP儿童在步态过程中感觉运动皮层和上级顶叶的激活量增加，2）CP儿童在其步幅时间间隔中有更大的变异性或错误，3）时间步态运动学中错误量的增加与皮层网络活动量的增加有关。我们的研究结果表明，围产期损伤和随后的神经重组发生痉挛性双瘫CP可能会影响功能性皮层活动控制步态。此外，我们的研究结果意味着增加皮层活动的躯体感觉皮层和上级顶叶皮层可能是基础的更大数额的错误，在时间步态运动学。
The primary aim of this exploratory investigation was to determine if there are differences in cortical activation of children with spastic diplegic cerebral palsy (CP) and typically developing children during gait. Functional near-infrared spectroscopy was used to measure the concentration of oxygenated hemoglobin that was present in the supplementary motor area, pre-central gyrus, post-central gyrus and superior parietal lobule as the children walked on a treadmill. A sagittal plane video was concurrently collected and later digitized to quantify the temporal gait variations. 1) The children with CP had an increased amount of activation in the sensorimotor cortices and superior parietal lobule during gait, 2) The children with CP had a greater amount of variability or error in their stride time intervals, and 3) an increased amount of error in the temporal gait kinematics was associated with an increased amount of activity across the cortical network. Our results suggest that the perinatal damage and subsequent neural reorganization that occurs with spastic diplegic CP may impact the functional cortical activity for controlling gait. Furthermore, our results imply the increased cortical activity of the somatosensory cortices and superior parietal cortices may underlie the greater amount of error in the temporal gait kinematics.
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影响因子：
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通讯作者：
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