NEURAL CADHERIN - ROLE IN SELECTIVE CELL-CELL ADHESION
NEURAL CADHERIN - ROLE IN SELECTIVE CELL-CELL ADHESION
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DOI：
10.1126/science.2762814
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发表时间：
1989-08-11
期刊：
影响因子：
56.9
通讯作者：
TAKEICHI, M
中科院分区：
文献类型：
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作者：
MIYATANI, S;SHIMAMURA, K;TAKEICHI, M
钙粘蛋白是钙离子依赖的细胞间粘附分子家族。克隆了编码小鼠神经钙粘蛋白（N-cadherin）的互补DNA，并检测了该分子的细胞结合特异性。小鼠N-cadherin与鸡的同源物在氨基酸序列上有92%的相似性，而与同种上皮钙粘蛋白和胎盘钙粘蛋白的相似性分别为49%和43%。在细胞结合试验中，小鼠N-钙粘蛋白不与其他小鼠钙粘蛋白交叉反应，但它确实与鸡N-钙粘蛋白交叉反应。结果表明，每种类型的钙粘蛋白赋予不同的细胞上的不同的粘附特异性，也是N-钙粘蛋白的特异性是保守的哺乳动物和鸟类细胞之间。
Cadherins are a family of Ca2+-dependent intercelular adhesion molecules. Complementary DNAs encoding mouse neural cadherin (N-cadherin) were cloned, and the cell binding specificity of this molecule was examined. Mouse N-cadherin shows 92 percent similarity in amino acid sequence to the chicken homolog, while it shows 49 pecent and 43 percent similarity to epithelial cadherin and to placental cadherin of the same species, respectively. In cell binding assays, mouse N-cadherin did not cross-react with other mouse cadherins, but it did cross-react with chicken N-cadherin. The results indicate that each cadherin type confers distinct adhesive specificities on different cells, and also that the specificity of N-cadherin is conserved between mammalian and avian cells.