Occupational IgE-mediated allergy after exposure to lupine seed flour
Occupational IgE-mediated allergy after exposure to lupine seed flour
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DOI：
10.1067/mai.2001.116860
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发表时间：
2001-08-01
影响因子：
14.2
通讯作者：
Muzquiz, M
中科院分区：
文献类型：
--
作者：
Crespo, JF;Rodríguez, J;Muzquiz, M
据报道，摄入羽扇豆籽粉（LSF）可引起过敏反应，特别是对花生过敏的患者，但很少有证据表明其吸入后具有致敏潜力。我们试图评估临床和免疫反应的员工与这种种子面粉工作羽扇豆氨酸。在某农业研究中心从事LSF工作的7名受试者（中位年龄35岁）具有职业史。三名受试者（1、6和7）在暴露于羽扇豆后立即报告了与工作相关的过敏症状。3例有工作相关症状的患者，LSF提取物皮肤点刺试验结果均为阳性。此外，受试者6和7中检测到羽扇豆素特异性IgE抗体。受试者6受控暴露于LSF后立即引起鼻眼症状，但FEV1没有变化。在受试者7中，LSF提取物的支气管刺激引起FEV1立即下降（25%）。受试者6和7的双盲、安慰剂对照LSF口服刺激结果为阳性。在受试者6和7中检测到对其他豆类的免疫反应性，但特异性吸入试验和口服激射结果均为阴性。因此，吸入羽扇豆粉可能是暴露工人过敏性致敏的重要原因，并可能引起职业性哮喘和食物过敏。
The ingestion of lupine seed flour (LSF) has been reported as a cause of allergic reactions, particularly in patients sensitized to peanut, but there is little evidence of its allergenic potential after inhalation. We sought to evaluate the clinical and immunologic reactivity to lupine in employees working with this seed flour. An occupational history was obtained in 7 subjects (median age, 35 years) working with LSF at an agricultural research center. Three subjects (1, 6, and 7) reported work-related allergy symptoms immediately after being exposed to lupine. Skin prick test results with LSF extract were positive in these 3 patients with work-related symptoms. Moreover, lupine-specific IgE antibodies were detected in subjects 6 and 7. In subject 6, the controlled exposure to LSF elicited immediate naso-ocular symptoms without changes in FEV1. In subject 7, a bronchial provocation with LSF extract elicited an immediate fall (25%) in FEV1. Double-blinded, placebo-controIled LSF oral challenge results were positive in subjects 6 and 7. Immunologic reactivity to other legumes was detected in subjects 6 and 7, but specific inhalation testing and oral challenge results were negative. Thus, the inhalation of lupine flour could be an important cause of allergic sensitization in exposed workers and might give rise to occupational asthma and food allergy.