The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
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DOI：
10.1254/jphs.09326sc
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Fujiwara, Michihiro
中科院分区：
文献类型：
--
作者：
Higuchi, Sei;Irie, Keiichi;Fujiwara, Michihiro
内源性大麻素已被证明激活奖励相关的喂养和促进星形胶质细胞分化。我们研究了高脂饮食（HFD）摄入是否通过内源性大麻素依赖机制产生对HFD的偏好。在条件性位置偏爱测试中，2周HFD摄入组显示出对HFD的偏好，并且下丘脑中反应性星形胶质细胞标记物胶质细胞酸性蛋白（GFAP）的表达增加。大麻素CB 1受体拮抗剂O-2050降低了HFD的偏好和下丘脑GFAP的表达。这些结果表明，HFD摄入导致的发展的偏好HFD通过星形胶质细胞CB 1受体在下丘脑。
Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD intake group showed preference for HFD and had increased expression of a marker for reactive astrocytes, glial fibrillary acid protein (GFAP), in the hypothalamus. The cannabinoid CB1-receptor antagonist O-2050 reduced the preference for HFD and expression of GFAP in the hypothalamus. These results suggested that HFD intake led to the development of a preference for HFD via astrocytic CB1 receptors in the hypothalamus.