Association between cystatin C and inflammation in patients with essential hypertension
Association between cystatin C and inflammation in patients with essential hypertension
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DOI：
10.1007/s10157-010-0334-8
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Higaki, Jitsuo
中科院分区：
文献类型：
--
作者：
Okura, Takafumi;Jotoku, Masanori;Higaki, Jitsuo
血清胱抑素C不仅是肾功能的标志，也是心血管损伤、心力衰竭和死亡的独立危险因素。众所周知，这些心血管事件的发生和发展有助于肾功能障碍和慢性炎症。在本研究中，我们研究了胱抑素C与促炎细胞因子的关系。88例原发性高血压患者参与了这项研究，测量了促炎细胞因子、肿瘤坏死因子(TNF)- α、白细胞介素(IL)-6和C反应蛋白（CRP）。胱抑素C与肾小球滤过率（eGFR） （r = -0.503, p < 0.001）、收缩压（r = -0.246, p = 0.034）和脉压（r = -0.295, p = 0.010）呈正相关。相反，血清肌酐仅与eGFR相关（r = -0.755, p < 0.001）， eGFR仅与年龄相关（r = -0.339, p = 0.001），而与其他临床参数无关，而胱抑素C也与ln自然（ln） IL-6 （r = -0.247, p = 0.033）和ln tnf - α (r = -0.405, p < 0.001)相关，但与CRP无关（r = -0.188, p = 0.108）。相比之下，血浆肌酐和eGFR与这些促炎细胞因子无关。逐步回归分析显示，ln tnf - α、eGFR和脉压是血清胱抑素C浓度的独立决定因素。本研究表明胱抑素C是炎症和肾功能的标志。
Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we investigated the relationship between cystatin C and proinflammatory cytokines.Eighty-eight patients with essential hypertension participated in the study, which involved measuring proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C reactive protein (CRP).Positive correlations were detected between cystatin C and estimated glomerular filtration rate (eGFR) (r = -0.503, p < 0.001), systolic blood pressure (r = -0.246, p = 0.034), and pulse pressure (r = -0.295, p = 0.010). In contrast, serum creatinine correlated only with eGFR (r = -0.755, p < 0.001) and eGFR correlated only with age (r = -0.339, p = 0.001) and not with the other clinical parameters, whereas cystatin C also correlated with log natural (ln) IL-6 (r = -0.247, p = 0.033) and ln TNF-alpha (r = -0.405, p < 0.001) but not with CRP (r = -0.188, p = 0.108). In contrast, plasma creatinine and eGFR did not correlate with any of these proinflammatory cytokines. Stepwise regression analysis showed that ln TNF-alpha, eGFR and pulse pressure were independent determinants of serum cystatin C concentration.This study showed that cystatin C is a marker of inflammation as well as renal function.