Interleukin (IL)-25: Pleiotropic roles in asthma
Interleukin (IL)-25: Pleiotropic roles in asthma
复制标题
白细胞介素 (IL)-25：在哮喘中的多效作用
作者：
Yao Xiujuan;Sun Yongchang;Wang Wei;Sun Ying
IL-25又称IL-17E，是IL-17细胞因子家族中的一员，能局部或系统地促进和增强辅助性T细胞2型(Th2)应答。越来越多的实验和临床研究表明，在哮喘条件下，IL-25及其同源受体IL-17RB/RA的表达显著上调。研究还发现，IL-25不仅可诱导典型的嗜酸性炎症和气道高反应性(AHR)，还可引起气道重塑，表现为杯状细胞增生、上皮下胶原沉积和血管生成。本文将对IL-25的发现、细胞来源和靶点进行综述，并试图对目前阐明IL-25在哮喘中的作用的动物和人类研究进行综述。我们的结论是，尽管IL-25是一种多效性细胞因子，但它可能只在特定的哮喘内型中起主导作用，被称为‘IL-25高’表型。因此，以IL-25或其受体为靶点可能会选择性地使某些哮喘亚群受益。此外，未来应评估哮喘多变环境中主要的IL-25产生细胞和反应细胞。
IL‐25, also named IL‐17E, is a distinct member of the IL‐17 cytokine family, which can promote and augment T helper type 2 (Th2) responses locally or systemically. Growing evidence from experimental and clinical studies indicates that the expression of IL‐25 and its cognate receptor, IL‐17RB/RA, is markedly upregulated in asthmatic conditions. It has also been found that IL‐25 induces not only typical eosinophilic inflammation and airway hyperresponsiveness (AHR), but also airway remodelling, manifested by goblet cell hyperplasia, subepithelial collagen deposition and angiogenesis. This review will focus on the discovery, cellular origins and targets of IL‐25, and try to update current animal and human studies elucidating the roles of IL‐25 in asthma. We conclude that although IL‐25 is a pleiotropic cytokine, it may only play its dominant role in a certain specific asthmatic endotype, named ‘IL‐25 high’ phenotype. Thus, targeting IL‐25 or its receptor might selectively benefit some subgroups with asthma. Furthermore, the major IL‐25 producing as well as responsive cells in the changeable milieu of asthma should be assessed in the future.