INFLUENCE OF SMOKING FEWER CIGARETTES ON EXPOSURE TO TAR, NICOTINE, AND CARBON-MONOXIDE
INFLUENCE OF SMOKING FEWER CIGARETTES ON EXPOSURE TO TAR, NICOTINE, AND CARBON-MONOXIDE
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DOI：
10.1056/nejm198611203152102
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发表时间：
1986-11-20
影响因子：
158.5
通讯作者：
YU, L
中科院分区：
文献类型：
--
作者：
BENOWITZ, NL;JACOB, P;YU, L
为了减少吸烟对健康的不良影响，医生经常建议无法戒烟的病人少吸烟。习惯性吸烟者可能会通过每支烟吸更多的烟来弥补香烟数量的减少。我们测量了短期限烟期间焦油（估计为尿液的致突变活性）、尼古丁和一氧化碳的摄入量。从平均每天39支香烟减少到平均每天5支香烟，每支香烟的烟草毒素摄入量增加了大约三倍，每天接触焦油和一氧化碳的量仅下降了50%。我们的结论是，少吸烟可能会减少接触毒素和相关的不良健康后果。然而，与维持尼古丁摄入量的趋势一致，益处的程度远低于预期。在长期限烟期间，“过度吸烟”是否持续，还需要进一步调查。
In the hope of reducing the adverse health consequences of smoking, physicians frequently advise their patients who cannot quit to smoke fewer cigarettes. Habitual smokers may compensate for the reduced number of cigarettes, by taking in more smoke per cigarette. We measured the intake of tar (estimated as mutagenic activity of the urine), nicotine, and carbon monoxide during short-term cigarette restriction. With a reduction from an average of 39 cigarettes to an average of 5 cigarettes per day, the intake of tobacco toxins per cigarette increased roughly threefold and daily exposure to tar and carbon monoxide declined only 50 percent. We conclude that smoking fewer cigarettes may reduce exposure to toxins and related adverse health consequences. However, consistent with a tendency to maintain intake of nicotine, the magnitude of the benefit is much less than expected. Whether "oversmoking" persists during long-term restriction of cigarettes requires further investigation.