Modulation of Retinal Arteriolar Central Reflection by APOE Genotype
Modulation of Retinal Arteriolar Central Reflection by APOE Genotype
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DOI：
10.2174/1567205014666170309115016
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发表时间：
2017-01-01
影响因子：
2.1
通讯作者：
Kanagasingam, Yogesan
中科院分区：
文献类型：
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作者：
Frost, Shaun;Bhuiyan, Alauddin;Kanagasingam, Yogesan
目的：研究视网膜小动脉中央反射（CR，视网膜血管照片中的中央反射），由于这些血管网络之间的同源性，可以提供视网膜和大脑微血管健康的信息。该研究还描述了一种新的基于计算机的半自动技术，该技术可以精确量化视网膜小动脉CR和血管宽度，并从数字视网膜照片中计算CR与血管宽度比（CRR）。方法：收集澳大利亚成像、生物标志物和生活方式研究（AIBL）参与者的数字视网膜照片，包括25名诊断为阿尔茨海默病（AD）的参与者（年龄72.4 +/- 7.5岁，12名男性，13名女性）和123名无痴呆的老年参与者（认知正常：CN）（年龄71.6 +/- 5.6岁，55名男性，68名女性）。采用新的CRR测量方法对144人（22 AD, 122 CN）进行亚队列研究，我们发现AD参与者的CRR水平显著高于CN参与者（平均CRR 0.253 (SD 0.04)）（平均CRR 0.231 (SD 0.04), p = 0.025）。然而，APOE ε 4等位基因状态的调整降低了显著性（p = 0.081）。APOE ε 4等位基因携带者的CRR（平均CRR 0.254 (SD 0.03)）显著高于非携带者（平均CRR 0.224 (SD 0.05), p < 0.0001）。结果：这些数据表明，CRR与APOE epsilon 4状态密切相关，与AD诊断表现出较弱的独立趋势。视网膜可能是一种新的模型，可用于无创监测APOE epsilon 4对中枢神经系统的影响，特别是在脑血管疾病中。
Objective: This study investigated the retinal arteriolar central reflex (CR, the central reflection observed in photographs of retinal vessels), which may provide information about micro-vascular health in the retina and also the brain, due to the homology between these vascular networks. The study also describes a novel computer based semi-automated technique that accurately quantifies retinal arteriolar CR and vessel width, and calculates the CR to vessel width ratio (CRR) from digital retinal photographs.Methods: Digital retinal photographs were collected from participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL), including 25 participants diagnosed with Alzheimer's disease (AD) (age 72.4 +/- 7.5 yrs, 12 male, 13 female) and 123 elderly participants without dementia (cognitively normals: CN) (age 71.6 +/- 5.6 yrs, 55 male, 68 female). Using a sub-cohort of 144 (22 AD, 122 CN) with the novel CRR measures, we identified significantly higher CRR levels in AD participants (mean CRR 0.253 (SD 0.04)) as compared with CN's (mean CRR 0.231 (SD 0.04), p = 0.025). Adjustment for APOE epsilon 4 allele status however, reduced the significance (p = 0.081). CRR was significantly higher in APOE epsilon 4 allele carriers (mean CRR 0.254 (SD 0.03) as compared with non-carriers (mean CRR 0.224 (SD 0.05), p < 0.0001).Results: These data indicate that CRR is strongly linked to APOE epsilon 4 status and exhibits a weaker, independent trend with AD diagnosis. The retina may be useful as a novel model for non-invasive monitoring of the effects of APOE epsilon 4 on the central nervous system, particularly in cerebrovascular disease.