Keratoconus prediction using a finite element model of the cornea with local biomechanical properties
Keratoconus prediction using a finite element model of the cornea with local biomechanical properties
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DOI：
10.1590/s0004-27492009000200002
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发表时间：
2009-04-01
影响因子：
1
通讯作者：
Chamon, Wallace
中科院分区：
文献类型：
--
作者：
Carvalho, Luis Alberto;Prado, Marcelo;Chamon, Wallace
目的：能够预测和了解哪些角膜的生物力学特性对圆锥角膜的稳定性或进展负责，这可能是眼科护理专业人员的重要临床和手术工具。我们已经开发了一个角膜的有限元模型，它试图根据角膜组织的材料特性来预测圆锥角膜的行为及其演变。方法：使用文献数据模拟角膜材料特性，角膜地形图基于示意图眼模型的文献值。商业软件被用来模拟角膜受到不同局部参数影响时的机械和表面特性，如弹性。结果：模拟结果表明，根据角膜的初始表面形状，局部材料特性的变化以及不同的眼压值会导致局部突起和曲率的增加，与角膜的剩余部分相比。结论：该技术为了解圆锥角膜的生物力学性质提供了一种定量和准确的方法。实施的模型表明，角膜局部材料特性和眼压的变化与圆锥角膜的病理及其形状/曲率有着内在的联系。
Purpose: The ability to predict and understand which biomechanical properties of the cornea are responsible for the stability or progression of keratoconus may be an important clinical and surgical tool for the eye-care professional. We have developed a finite element model of the cornea, that tries to predicts keratoconus-like behavior and its evolution based on material properties of the corneal tissue. Methods: Corneal material properties were modeled using bibliographic data and corneal topography was based on literature values from a schematic eye model. Commercial software was used to simulate mechanical and surface properties when the cornea was subject to different local parameters, such as elasticity. Results: The simulation has shown that, depending on the corneal initial surface shape, changes in local material properties and also different intraocular pressures values induce a localized protuberance and increase in curvature when compared to the remaining portion of the cornea. Conclusions: This technique provides a quantitative and accurate approach to the problem of understanding the biomechanical nature of keratoconus. The implemented model has shown that changes in local material properties of the cornea and intraocular pressure are intrinsically related to keratoconus pathology and its shape/curvature.