Revisiting the notion of deleterious sweeps.
Revisiting the notion of deleterious sweeps.
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重新审视有害扫描的概念。
DOI：
10.1093/genetics/iyab094
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发表时间：
2021
期刊：
影响因子：
3.3
通讯作者：
Jensen,JeffreyD
中科院分区：
文献类型：
--
作者：
Johri,Parul;Charlesworth,Brian;Howell,EmmaK;Lynch,Michael;Jensen,JeffreyD
以前已经证明，在固定的条件下，在随机交配的种群中，半显性有害常染色体突变的固定时间与优势突变的固定时间相同。这一结果意味着有害的突变可能会产生选择性的扫荡效应。尽管它们的固定概率差异很大，但相对于有益突变，有害突变的投入要大得多，这表明这种现象可能是重要的。在这里，我们研究了轻微有害突变的固定如何影响链接位点的多态水平和模式-在有害突变之间存在和不存在干扰-以及这类位点如何有助于种群和物种之间的差异。我们发现，虽然有害的注视不太可能代表群体内基于多态的基因组扫描中的很大比例的异常值，但有害突变频率的微小变化可以影响私人变异的比例和最近的群体分裂后FST的价值。由于有害突变的位点必然在功能基因组区域中被发现，因此对反复的正选择的解释可能需要重新考虑。
It has previously been shown that, conditional on its fixation, the time to fixation of a semi-dominant deleterious autosomal mutation in a randomly mating population is the same as that of an advantageous mutation. This result implies that deleterious mutations could generate selective sweep-like effects. Although their fixation probabilities greatly differ, the much larger input of deleterious relative to beneficial mutations suggests that this phenomenon could be important. We here examine how the fixation of mildly deleterious mutations affects levels and patterns of polymorphism at linked sites—both in the presence and absence of interference amongst deleterious mutations—and how this class of sites may contribute to divergence between-populations and species. We find that, while deleterious fixations are unlikely to represent a significant proportion of outliers in polymorphism-based genomic scans within populations, minor shifts in the frequencies of deleterious mutations can influence the proportions of private variants and the value ofFSTafter a recent population split. As sites subject to deleterious mutations are necessarily found in functional genomic regions, interpretations in terms of recurrent positive selection may require reconsideration.