Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study
Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study
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DOI：
10.1111/j.1600-6143.2012.04028.x
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发表时间：
2012-07-01
影响因子：
8.8
通讯作者：
Rimola, A.
中科院分区：
文献类型：
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作者：
Miro, J. M.;Montejo, M.;Rimola, A.
84例HCV/HIV合并感染和252例匹配的HCV单一感染肝移植受者被纳入一项前瞻性多中心研究。36例（43%）HCV/HIV合并感染和75例（30%）HCV单一感染患者死亡，5年生存率分别为54%（95%CI，4264）和71%（95%CI，66 - 77; p = 0.008）。当两组合并考虑时，HIV感染是死亡率的独立预测因子（HR，2.202; 95%CI，1.420 - 3.413 [p < 0.001]）。仅对HCV/HIV合并感染的受者进行多因素分析，发现HCV基因型1（HR，2.98; 95% CI，1.326.76）、供体风险指数（HR，9.48; 95% CI，2.7532.73）和血浆HCV RNA阴性（HR，0.14; 95% CI，0.030.62）与死亡率相关。当这项分析仅限于移植前变量时，我们确定了三个独立因素（HCV基因型1，移植前MELD评分和中心与
Eighty-four HCV/HIV-coinfected and 252-matched HCV-monoinfected liver transplant recipients were included in a prospective multicenter study. Thirty-six (43%) HCV/HIV-coinfected and 75 (30%) HCV-monoinfected patients died, with a survival rate at 5 years of 54% (95% CI, 4264) and 71% (95% CI, 66 to 77; p = 0.008), respectively. When both groups were considered together, HIV infection was an independent predictor of mortality (HR, 2.202; 95% CI, 1.4203.413 [p < 0.001]). Multivariate analysis of only the HCV/HIV-coinfected recipients, revealed HCV genotype 1 (HR, 2.98; 95% CI, 1.326.76), donor risk index (HR, 9.48; 95% CI, 2.7532.73) and negative plasma HCV RNA (HR, 0.14; 95% CI, 0.030.62) to be associated with mortality. When this analysis was restricted to pretransplant variables, we identified three independent factors (HCV genotype 1, pretransplant MELD score and centers with