Consistent Spatial-Temporal Longitudinal Atlas Construction for Developing Infant Brains.
Consistent Spatial-Temporal Longitudinal Atlas Construction for Developing Infant Brains.
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DOI：
10.1109/tmi.2016.2587628
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发表时间：
2016-12
影响因子：
10.6
通讯作者：
Shen D
中科院分区：
文献类型：
--
作者：
Zhang Y;Shi F;Wu G;Wang L;Yap PT;Shen D
脑图谱是了解脑动态发育的重要组成部分，特别是在出生后早期。然而，纵向地图集是罕见的婴儿，现有的一般是有限的，他们的模糊外观。此外，由于纵向图谱构建通常随时间独立执行，因此构建的图谱通常无法保持时间一致性。对于婴儿图像，该问题进一步恶化，因为它们通常具有低空间分辨率和不足的组织对比度。在本文中，我们提出了一个新的框架一致的时空建设的纵向地图集开发婴儿大脑MR图像。具体而言，为了保持结构细节，同时在时空小波域中执行图谱构建。这通过来自每个频率子带的结果的基于补丁的组合来实现。与现有的婴儿纵向图谱相比，我们的实验结果表明，我们的方法是能够产生更丰富的结构细节和更好的纵向一致性的纵向图谱，从而导致更高的性能时，用于空间归一化的一组婴儿大脑图像。
Brain atlases are an essential component in understanding the dynamic cerebral development, especially for the early postnatal period. However, longitudinal atlases are rare for infants, and the existing ones are generally limited by their fuzzy appearance. Moreover, since longitudinal atlas construction is typically performed independently over time, the constructed atlases often fail to preserve temporal consistency. This problem is further aggravated for infant images since they typically have low spatial resolution and insufficient tissue contrast. In this paper, we propose a novel framework for consistent spatial-temporal construction of longitudinal atlases for developing infant brain MR images. Specifically, for preserving structural details, the atlas construction is performed in spatial-temporal wavelet domain simultaneously. This is achieved by a patch-based combination of results from each frequency subband. Compared with the existing infant longitudinal atlases, our experimental results indicate that our approach is able to produce longitudinal atlases with richer structural details and also better longitudinal consistency, thus leading to higher performance when used for spatial normalization of a group of infant brain images.