PARKINSONS-DISEASE - A CASE-CONTROL STUDY OF OCCUPATIONAL AND ENVIRONMENTAL RISK-FACTORS
PARKINSONS-DISEASE - A CASE-CONTROL STUDY OF OCCUPATIONAL AND ENVIRONMENTAL RISK-FACTORS
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DOI：
10.1002/ajim.4700170307
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发表时间：
1990-01-01
影响因子：
3.5
通讯作者：
CALNE, D
中科院分区：
文献类型：
--
作者：
HERTZMAN, C;WIENS, M;CALNE, D
我们比较了57例患者和122名年龄匹配的对照者的个人病史，以确定帕金森病（PD）的可能环境决定因素。采用逐步logistic回归计算经性别、年龄和吸烟校正后的比值比（OR）。我们发现，在果园工作的风险有统计学显著性增加（OR = 3.69，p = 0.012，95%CI = 1.34，10.27），在刨床米尔斯工作的风险有轻微显著性增加（OR = 4.11，p = 0.065，95%CI = 0.91，18.50）。对帕金森病的发生与（1）百草枯接触和（2）姿势性震颤之间的关联进行Fisher精确检验，得出的统计学显著性概率估计值分别为0.01和0.03。PD的相对风险随着吸烟而降低，许多研究支持这种反比关系。
We compared personal histories of 57 cases and 122 age-matched controls to identfy possible environmental determinants of Parkinson''s disease (PD). Odds ratios (OR) adjusted for sex, age, and smoking were computed using stepwise logistic regression. We found a statistically significant increased risk for working in orchards (OR = 3.69, p = 0.012, 95% CI = 1.34, 10.27) and a marginally significant increased risk associated with working in planer mills (OR = 4.11, p = 0.065, 95% CI = 0.91, 18.50). A Fisher''s exact test of the association between PD development and (1) paraquat contact, and (2) postural tremor gave statistically significant probability estimates of 0.01 and 0.03, respectively. The relative risk of PD decreased with smoking, an inverse relationship supported by many studies.