Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis
Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis
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DOI：
10.1007/s11419-009-0088-8
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Ikeda, Noriaki
中科院分区：
文献类型：
--
作者：
Kudo, Keiko;Ishida, Tomomi;Ikeda, Noriaki
由于当地的环境、文化和宗教状况，中毒的模式在不同的国家是不同的。因此，在日本，通过建立一个有效的系统的毒物分析系统，了解我国的中毒模式，并为每一个中毒案件做好准备，在法医实践中是非常重要的。根据警察科学研究所和日本法律的医学会2003年至2006年的两个系列报告，我们对引起中毒的化合物种类及其使用频率进行了回顾性研究。从这些报告中，459和177的化合物，分别被提取为有毒化合物在研究期间。经过数据分析，我们选择了314种药物和毒物作为日本系统药物分析的重要目标化合物，其中包括36种挥发性化合物，14种滥用药物，170种医疗药物，60种农药，13种天然毒素和21种其他药物。这是首次根据使用频率显示日本需要分析的有毒药物和毒药的研究，因此该列表将有助于建立法医实践中最有效的筛选系统。
Patterns of poisoning are known to be different in different countries, because of the local environmental, cultural, and religious situations. Therefore, in Japan, it is important to know the pattern of poisoning in our own country and to prepare for every poisoning case by establishing an efficient systematic toxicological analysis system in forensic practice. We conducted a retrospective study of the kinds of compounds causing poisonings and the frequency of their use based on two series of reports dealing with poisoning cases in Japan prepared by the National Research Institute of Police Science and the Japanese Society of Legal Medicine for 2003 to 2006. From these reports, 459 and 177 compounds, respectively, were extracted as poisonous compounds over the study period. After data analysis, we selected 314 drugs and poisons as important target compounds for systematic drug analysis in Japan; they included 36 volatile compounds, 14 abused drugs, 170 medical drugs, 60 pesticides, 13 natural toxins, and 21 others. This is the first study to show the toxic drugs and poisons to be analyzed in Japan based on frequency of use, and as such the list will be useful in establishing the most efficient screening system in forensic practice.