Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes
Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes
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DOI：
10.1002/ardp.200700040
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Massabni, Antonio C.
中科院分区：
文献类型：
--
作者：
Cavicchioli, Mauricio;Leite, Clarice Q. F.;Massabni, Antonio C.
本文介绍了以阿斯巴甜、糖精和甜蜜素为配体的三种Ag(I)-配合物的合成及其抑菌活性，旨在寻找新的抗结核和其他分枝杆菌感染的候选物质。研究了这三种复合物的最低抑菌浓度，以确定它们对结核分枝杆菌、鸟分枝杆菌、胞内分枝杆菌、马尔默氏分枝杆菌和堪萨斯分枝杆菌的体外抑菌活性。MIC值采用微孔板Alamar Blue Assay测定。这两种复合物的最佳MIC值分别为：Ag(1)-阿斯巴甜对堪萨斯结核分枝杆菌的MIC值为9.75 μ M, Ag(1)-甜蜜素对结核分枝杆菌的MIC值为15.7 μ M。
The present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis.